All comparisons
Compared with GraphPad Prism
Dose-response fitting compared with GraphPad Prism
One job per row: Drybench Assay beside GraphPad's own guide to Prism, including what Drybench does not do.
Job by job
Vendor statements read on 8 November 2026.
| Job | Drybench | GraphPad Prism |
|---|---|---|
| Four-parameter dose-response fit | IC50 and EC50 calculator with confidence intervals | Prism's variable-slope model fits the Hill slope from the data rather than assuming a standard slope. GraphPad's page, read 8 November 2026 |
| Confidence intervals for the fitted parameters | 4PL IC50 Example: C03 Plateau Coverage and Uncertainty | Prism offers two methods for computing the confidence intervals of fitted parameters. GraphPad's page, read 8 November 2026 |
| Comparing two models | Six rules that show a C50 or withhold it with the reason, a relative or absolute C50, Z′ per plate and model comparison by F-test or AICc (F-test checked against R; AICc unit-tested only) | Prism compares two fits by the extra sum-of-squares F test or by Akaike's information criterion. GraphPad's page, read 8 November 2026 |
| Assay quality by Z′ | Z prime factor calculator | A GraphPad FAQ dated September 2010 says no GraphPad program computes the Z-factor, and that Prism's row or column statistics give the means and SDs to work it out. GraphPad's page of September 2010, read 8 November 2026 |
| Unknowns from a standard curve | ELISA standard curve: interpolate unknown samples | Prism interpolates unknowns from a standard (calibration) curve entered above them in the same table. GraphPad's page, read 8 November 2026 |
| Reproducing the fit in other software | A citable method block, a CSV for GraphPad Prism (XY table) and an R snippet (drc::drm), so the fit can be reproduced elsewhere, with structures beside potencies when a SMILES column is present (the export has not been fitted in Prism; Prism's weighting and interval defaults are not reproduced) | Prism imports text files delimited by tabs (.txt) or commas (.csv). GraphPad's page, read 8 November 2026 |
| Outliers removed by robust fitting | Not in Drybench | With the ROUT option, Prism identifies outliers, removes them and fits the remaining points. GraphPad's page, read 8 November 2026 |
| Graphs styled for publication | Not in Drybench | Prism lets you choose a graph type and change the data arrangement, point style, labels, fonts and colours as you go. GraphPad's page, read 8 November 2026 |
Four-parameter dose-response fit
- GraphPad Prism
- Prism's variable-slope model fits the Hill slope from the data rather than assuming a standard slope. GraphPad's page, read 8 November 2026
Confidence intervals for the fitted parameters
- GraphPad Prism
- Prism offers two methods for computing the confidence intervals of fitted parameters. GraphPad's page, read 8 November 2026
Comparing two models
- Drybench
- Six rules that show a C50 or withhold it with the reason, a relative or absolute C50, Z′ per plate and model comparison by F-test or AICc (F-test checked against R; AICc unit-tested only)
- GraphPad Prism
- Prism compares two fits by the extra sum-of-squares F test or by Akaike's information criterion. GraphPad's page, read 8 November 2026
Assay quality by Z′
- Drybench
- Z prime factor calculator
- GraphPad Prism
- A GraphPad FAQ dated September 2010 says no GraphPad program computes the Z-factor, and that Prism's row or column statistics give the means and SDs to work it out. GraphPad's page of September 2010, read 8 November 2026
Unknowns from a standard curve
- GraphPad Prism
- Prism interpolates unknowns from a standard (calibration) curve entered above them in the same table. GraphPad's page, read 8 November 2026
Reproducing the fit in other software
- Drybench
- A citable method block, a CSV for GraphPad Prism (XY table) and an R snippet (drc::drm), so the fit can be reproduced elsewhere, with structures beside potencies when a SMILES column is present (the export has not been fitted in Prism; Prism's weighting and interval defaults are not reproduced)
- GraphPad Prism
- Prism imports text files delimited by tabs (.txt) or commas (.csv). GraphPad's page, read 8 November 2026
Outliers removed by robust fitting
- Drybench
- Not in Drybench
- GraphPad Prism
- With the ROUT option, Prism identifies outliers, removes them and fits the remaining points. GraphPad's page, read 8 November 2026
Graphs styled for publication
- Drybench
- Not in Drybench
- GraphPad Prism
- Prism lets you choose a graph type and change the data arrangement, point style, labels, fonts and colours as you go. GraphPad's page, read 8 November 2026
For research and education only, not for diagnosis, treatment or investment decisions. The table compares what each tool does, and no result from either has been checked against the other. On a Drybench page, verified means checked against an automated reference, not by an independent reviewer.
GraphPad and Prism are trademarks of GraphPad Software LLC (Dotmatics). Drybench is not affiliated with, endorsed by or sponsored by GraphPad Software LLC.
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