Methods and checks

How each Drybench app reaches its results: which method every calculator, analysis and view uses, the references behind it, and how far each method has been checked.

What the levels mean

Drybench Protein

Search a protein and see its experimental structure beside the AlphaFold model, and the drugs that act on it.

Methods and checks for Drybench Protein · This page as Markdown

• Retained structure evidence: Tested, not reference-checked
• Experimental structure evidence: Tested, not reference-checked
• Source confidence and exact residue transfer: Checked against a reference
• Dossier: No method record is kept for this view, so it carries no level.
• Compare: No method record is kept for this view, so it carries no level.
• Check a substitution: No method record is kept for this view, so it carries no level.
• Compare with another entry: No method record is kept for this view, so it carries no level.

Drybench Molecule

Draw or paste a molecule and see how drug-like it is, beside 2,197 approved drugs.

Methods and checks for Drybench Molecule · This page as Markdown

• Scorecard: Tested, not reference-checked
• Compare: Tested, not reference-checked

Drybench Pipeline

Trials for any condition from ClinicalTrials.gov, US approvals from openFDA, and the FDA precedent behind them.

Methods and checks for Drybench Pipeline · This page as Markdown

• Landscape: No method record is kept for this view, so it carries no level.
• Trials: No method record is kept for this view, so it carries no level.
• Charts: No method record is kept for this view, so it carries no level.
• US approvals: No method record is kept for this view, so it carries no level.
• FDA precedent: Tested, not reference-checked

Drybench Cell

From gene to working protein, in eight real human structures.

Methods and checks for Drybench Cell · This page as Markdown

• The tour: No method record is kept for this step, so it carries no level.

Drybench Patent

Listed patents and exclusivities for a US product, each date traced to its Orange Book or Purple Book rule.

Methods and checks for Drybench Patent · This page as Markdown

• Protection: No method record is kept for this view, so it carries no level.
• Patents: No method record is kept for this view, so it carries no level.
• Exclusivity: No method record is kept for this view, so it carries no level.
• Generics and Paragraph IV: No method record is kept for this view, so it carries no level.
• Changes: No method record is kept for this view, so it carries no level.
• Date window: No method record is kept for this view, so it carries no level.

Drybench Calc

Molarity, dilutions, serial plans, A280 and buffers with units on every field and the method beside each answer.

Methods and checks for Drybench Calc · This page as Markdown

• Molarity and stocks: Checked against a reference
• Recipe table: Checked against a reference
• Percent solutions: Checked against a reference
• Buffer pKa at temperature: Checked against a reference
• C1V1 dilution: Checked against a reference
• Serial dilution: Tested, not reference-checked
• Antibody dilution: Checked against a reference
• Master mix: Checked against a reference
• A280 and A260: Checked against a reference
• Cell seeding and splitting: Checked against a reference
• Cell counting and viability: Checked against a reference
• Cells from OD600 (estimate): Tested, not reference-checked
• Dose per cell: Checked against a reference
• RCF and RPM: Checked against a reference
• Unit converter: Checked against a reference

Drybench Sequence

Reverse complement, translation, ORFs, protein MW and pI, and primer checks from one paste, with the method named.

Methods and checks for Drybench Sequence · This page as Markdown

• Reverse complement: No method record is kept for this tool, so it carries no level.
• Translate: Checked against a reference
• Six frames: Checked against a reference
• Open reading frames: Checked against a reference
• Protein MW and pI: Tested, not reference-checked
• ε280: Checked against a reference
• GC percent: No method record is kept for this tool, so it carries no level.
• DNA molecular weight: Checked against a reference
• Motif search: No method record is kept for this tool, so it carries no level.
• Oligo Tm: Checked against a reference
• Primer check: Tested, not reference-checked
• Primer design: Checked against a reference
• Mutagenesis primers: Checked against a reference
• Review sequence revisions: Checked against a reference
• Find DNA fragment: Checked against a reference

Drybench Assay

Dose-response, standard curves and qPCR with explicit methods and retained research context.

Methods and checks for Drybench Assay · This page as Markdown

• Dose response: Tested, not reference-checked
• Weighted fit (1/Y²): Tested, not reference-checked
• Plate quality: Tested, not reference-checked
• Outlier candidates and influence: Tested, not reference-checked
• Curve shape and model choice: Tested, not reference-checked
• Comparing curves and experiments: Tested, not reference-checked
• Agonist and antagonist analyses: Tested, not reference-checked
• Reporter, viability and kinetic readings: Tested, not reference-checked
• Molar units and ligand efficiency: Tested, not reference-checked
• Where to add a concentration: Tested, not reference-checked
• Standard curve: Checked against a reference
• qPCR relative expression: Tested, not reference-checked
• Growth: selected window: Tested, not reference-checked
• Enzyme kinetics: initial rates: Tested, not reference-checked
• Enzyme kinetics: inhibition: Checked against a reference
• Thermal shift: apparent Tm: Tested, not reference-checked
• Screening campaign: Tested, not reference-checked
• Descriptive statistics: Checked against a reference
• Power and sample size: Checked against a reference
• Several groups: one factor: Checked against a reference
• False discovery rate: Checked against a reference
• Survival curves: Checked against a reference
• Compare proportions: Checked against a reference
• Correlation: Checked against a reference
• GR metrics: GR50, GRmax and GR_AOC: Tested, not reference-checked
• Competition and saturation binding: Checked against a reference
• Combination responses: Checked against a reference

Drybench Plasmid

What is in this plasmid, and which digest proves it: annotated maps, a schematic gel and sequencing-primer sites.

Methods and checks for Drybench Plasmid · This page as Markdown

• Map: Tested, not reference-checked
• Features: Tested, not reference-checked
• Digest: Tested, not reference-checked
• Sequence: No method record is kept for this view, so it carries no level.
• Numbers: Checked against a reference
• Explainers: No method record is kept for this view, so it carries no level.
• Assembly: Tested, not reference-checked
• SpCas9 guide sites: Checked against a reference

Drybench Bioreactor

Batch, fed-batch and chemostat runs with cited presets, showing when oxygen runs out and what would rescue it.

Methods and checks for Drybench Bioreactor · This page as Markdown

• Run: Tested, not reference-checked
• Rescue: Tested, not reference-checked
• Pump sheet: Checked against a reference
• Measured data beside this run: Checked against a reference
• New comparison: Checked against a reference
• kLa calculator: Checked against a reference
• OTR and OUR calculator: Checked against a reference
• Scale-up calculator: Checked against a reference