{
 "about": {
  "method": "agonist and antagonist analyses (Gaddum/Schild, Gaddum non-competitive, operational model)",
  "origin": "Original synthetic data (known models plus a fixed noise vector), not experimental",
  "ruling": "CSO memo of 13 October 2026 (docs/board/memos/2026-10-13-cso-agonist-antagonist.md)",
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   "schild": "logEC50([B]) = logEC50_0 + log10(1 + ([B] 10^pA2)^s), Top, Bottom, Hill shared",
   "operational": "E = basal + (Em - basal)/(1 + ((A + KA)/(tau A))^n)",
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   "profile": "bounds within 1e-3",
   "F": "within 1e-5 relative; p within 1e-4 relative",
   "gaddum": "KB within 1e-4 relative; log KB within 1e-4",
   "status": "exact, with the reason"
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  "recordedOn": "2026-10-13",
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   "cpu": "AMD EPYC 7763 64-Core Processor",
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   "openblasCore": "Haswell",
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   "version": "R version 4.4.3 (2025-02-28)",
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