{
 "about": {
  "method": "inhibition-profile-interval",
  "origin": "Original synthetic rates from known parameters with recorded noise vectors (NumPy default_rng seeds named per case); the coverage replicates from seeded generators",
  "ruling": "CSO memo of 11 October 2026, item 8 (docs/board/memos/2026-10-11-cso-assay-depth-stage.md); roadmap A5",
  "pointEstimate": "inhibition_global.py's method in the engine's dimensionless coordinates",
  "threshold": "RSS_min (1 + F(0.95; 1, n - p)/(n - p)), one constant at a time",
  "search": "0.02, 0.04, 0.08, ... ln units outward, last step clamped to the box; brentq xtol 1e-12; warm-started refits",
  "poorlyDetermined": "any constant's interval wider than two log10 units, or unresolved on a side",
  "coverage": {
   "replicates": 1000,
   "seed": 20261020,
   "noise": "Gaussian, SD 0.15 on Vmax 10 (1.5 percent)",
   "unresolvedSides": "counted as open to the box",
   "designs": [
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     "model": "competitive",
     "truth": {
      "ki": 5.0
     },
     "replicates": 1000,
     "withoutEstimate": 0.0,
     "ki": {
      "coverage": 0.938,
      "wilson95": [
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      "unresolvedFraction": 0.0
     }
    },
    {
     "model": "mixed",
     "truth": {
      "ki": 3.0,
      "kiPrime": 30.0
     },
     "replicates": 1000,
     "withoutEstimate": 0.0,
     "ki": {
      "coverage": 0.949,
      "wilson95": [
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      "unresolvedFraction": 0.0
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     "kiPrime": {
      "coverage": 0.949,
      "wilson95": [
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      "unresolvedFraction": 0.0
     }
    }
   ],
   "gate": "every constant of every design must cover at least 0.90 before the copy says approximate 95 percent",
   "gatePassed": true
  },
  "tolerances": {
   "resolved bounds": "within 1e-3 ln units of the direct profile",
   "threshold": "within 1e-8 relative",
   "estimates": "within 1e-5 relative",
   "side states, reasons, not-available reasons and the poorly-determined flag": "exact"
  },
  "recordedOn": "2026-10-13",
  "script": "pipeline/assay-analyser/oracles/inhibition_profile.py",
  "scriptSha256": "5d3789c752c2fafa320356fe1e86ca2be2cfb2b4146c5f5e4acd6dbcfbf7f35c",
  "helper": {
   "script": "pipeline/assay-analyser/oracles/stage_a_oracle.py",
   "sha256": "492d85ca2fa6750db80b1c64214fd4a0b13cd4c588267244f6262c504c73e3e8"
  },
  "environment": {
   "image": "ghcr.io/biotechmat/drybench/oracle-env:11b8a5e4456df7eb@sha256:7e69891ca1d9f24838660e0a9887bdb654ce7771d2f2ac7e7275e9b1eb3b6a09",
   "r": "R version 4.4.3 (2025-02-28)",
   "packages": {},
   "python": "3.11.15",
   "numpy": "2.0.2",
   "scipy": "1.13.1",
   "recordedOn": "2026-10-13",
   "cpu": "AMD EPYC 9V45 96-Core Processor",
   "cpuClass": "x86-64-v3",
   "simd": [
    "SSSE3",
    "SSE41",
    "POPCNT",
    "SSE42",
    "AVX",
    "F16C",
    "FMA3",
    "AVX2"
   ],
   "openblasCore": "Haswell",
   "threads": 1
  },
  "crossCheck": {
   "tool": "R",
   "ran": false,
   "reason": "The CSO named a SciPy direct profile with its coverage run as the oracle for this item (memo of 11 October 2026, item 8); no R cross-check is named"
  }
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 "oracle": {
  "engine": "scipy.optimize.least_squares",
  "method": "trf with bounds for the fit and each refit; scipy.stats.f.ppf; scipy.optimize.brentq"
 },
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