{
 "about": {
  "method": "design-narrowing",
  "methodVersion": "1.0.0",
  "memo": "docs/board/memos/2026-10-13-cso-a4-diagnostics.md",
  "tolerances": {
   "variance": "1e-6 relative",
   "currentHalfWidth": "1e-6 relative",
   "chosen candidate and kind": "exact",
   "replicates, narrowingRounded and shown": "exact"
  },
  "origin": "The worked MTT plate (pipeline/assay-analyser/fixtures/mtt-example.json) and constructed curves (seeded noise, numpy default_rng); estimates from this script's own SciPy fit, given to the engine as stored estimates",
  "recordedOn": "2026-10-13",
  "script": "pipeline/assay-analyser/oracles/design_narrowing.py",
  "scriptSha256": "d31d23bb1c37c6b0c1b9a6d68cc2ee0d154b69dc260b5d423fb6c50f6adb0e71",
  "helper": {
   "script": "pipeline/assay-analyser/oracles/stage_a_oracle.py",
   "sha256": "492d85ca2fa6750db80b1c64214fd4a0b13cd4c588267244f6262c504c73e3e8"
  },
  "environment": {
   "image": "ghcr.io/biotechmat/drybench/oracle-env:11b8a5e4456df7eb@sha256:7e69891ca1d9f24838660e0a9887bdb654ce7771d2f2ac7e7275e9b1eb3b6a09",
   "r": "R version 4.4.3 (2025-02-28)",
   "packages": {
    "drc": "4.0-0",
    "jsonlite": "2.0.0"
   },
   "python": "3.11.15",
   "numpy": "2.0.2",
   "scipy": "1.13.1",
   "recordedOn": "2026-10-13",
   "cpu": "AMD EPYC 7763 64-Core Processor",
   "cpuClass": "x86-64-v3",
   "simd": [
    "SSSE3",
    "SSE41",
    "POPCNT",
    "SSE42",
    "AVX",
    "F16C",
    "FMA3",
    "AVX2"
   ],
   "openblasCore": "Haswell",
   "threads": 1
  },
  "crossCheck": {
   "tool": "base R, finite-difference Jacobian at drc LL.4 estimates",
   "ran": true,
   "r": "R version 4.4.3 (2025-02-28)",
   "drc": "4.0.0",
   "worstRelativeVariance": 1.3960735222331153e-08,
   "chosenAgrees": true,
   "note": "drc's estimates differ from SciPy's at its own tolerance, so V_c is compared at 1e-4 relative here; the 1e-6 tolerance is the engine's against this fixture",
   "agrees": true
  }
 },
 "cases": [
  {
   "name": "Compound A",
   "about": "The worked MTT plate, Compound A",
   "curve": {
    "id": "Compound A",
    "x": [
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    "fixed": {}
   },
   "estimates": {
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    "bottom": 3.0369018010253126,
    "logIC50": -5.665647204192236,
    "hill": -1.2823903912343009
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    "narrowingRounded": 15,
    "shown": true
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  },
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   "name": "Compound B",
   "about": "The worked MTT plate, Compound B",
   "curve": {
    "id": "Compound B",
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    "fixed": {}
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   "estimates": {
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    "narrowingRounded": 15,
    "shown": true
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  },
  {
   "name": "one-on-the-slope",
   "about": "A steep curve with one concentration on its slope: a midpoint beside the C50 should win",
   "curve": {
    "id": "slope",
    "x": [
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    "y": [
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    "fixed": {}
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   "estimates": {
    "top": 98.26908760584178,
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   "expected": {
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     {
      "x": -8.25,
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      "halfWidth": 0.09084703472619413
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     {
      "x": -7.75,
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     {
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     {
      "x": -5.75,
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      "variance": 0.001612223085747006,
      "halfWidth": 0.08253464142082255
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     {
      "x": -5.25,
      "kind": "midpoint",
      "variance": 0.0020683379678914653,
      "halfWidth": 0.09348339004974582
     },
     {
      "x": -4.75,
      "kind": "midpoint",
      "variance": 0.002088620649566958,
      "halfWidth": 0.09394063352793958
     },
     {
      "x": -4.25,
      "kind": "midpoint",
      "variance": 0.002086496302127741,
      "halfWidth": 0.0938928476089947
     },
     {
      "x": -9.0,
      "kind": "beyond",
      "variance": 0.0019512239349311624,
      "halfWidth": 0.09079820402424242
     },
     {
      "x": -3.5,
      "kind": "beyond",
      "variance": 0.0020862431445998753,
      "halfWidth": 0.09388715136064606
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    ],
    "chosen": {
     "x": -6.5,
     "kind": "midpoint"
    },
    "narrowing": 71.87982383481167,
    "narrowingRounded": 70,
    "shown": true
   }
  },
  {
   "name": "thin-plateau",
   "about": "The lower plateau (high concentrations) has one concentration at or beyond its bend point: the step beyond the top should win",
   "curve": {
    "id": "plateau",
    "x": [
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    "y": [
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